Healthy Action Australia > Nutritional Supplements

Vitamin K - Perhaps This Will Be One of The Greatest Vitamin Discoveries Yet... 

Vitamin K may very well be “the next vitamin D” as research continues to illuminate a growing number of benefits to your health.

It is probably where vitamin D was ten years ago with respect to its appreciation as a vital nutrient that has far more benefits than was originally recognized.

And, according to Dr. Cees Vermeer, one of the world’s top researchers in the field of vitamin K, nearly everyone is deficient in vitamin K – just like most are deficient in D.

Vitamin K measurements in blood plasma can be done accurately, but the results are not necessarily helpful because they mainly reflect what you ate yesterday. Because of this, we will have to trust Dr. Vermeer on his assessment that most are too deficient to reap all of its health benefits. Vitamin K researchers across the world will acknowledge him as a leader in this field.

Most people get enough K from their diets to maintain adequate blood clotting, but NOT enough to offer protection against the following health problems—and the list is growing:

•Arterial calcification, cardiovascular disease and varicose veins
•Osteoporosis
•Prostate cancer, lung cancer, liver cancer and leukemia
•Brain health problems, including dementia, the specifics of which are still being studied
Vitamin K comes in two forms, and it is important to understand the differences between them before devising your nutritional plan of attack.

The Two Basic Types of Vitamin K

Vitamin K can be classified as either K1 or K2:

1.Vitamin K1: Found in green vegetables, K1 goes directly to your liver and helps you maintain a healthy blood clotting system. (This is the kind of K that infants need to help prevent a serious bleeding disorder.) It is also vitamin K1 that keeps your own blood vessels from calcifying, and helps your bones retain calcium and develop the right crystalline structure.

2.Vitamin K2: Bacteria produce this type of vitamin K. It is present in high quantities in your gut, but unfortunately is not absorbed from there and passes out in your stool. K2 goes straight to vessel walls, bones, and tissues other than your liver. It is present in fermented foods, particularly cheese and the Japanese food natto, which is by far the richest source of K2.
Vitamin K1 can convert to K2 in your body, but there are some problems with this, which I will discuss shortly. As a supplement, K1 is less expensive, which is why it’s the form used for neonates.

Making matters even more complex, there are several different forms of vitamin K2.

MK8 and MK9 come primarily from dairy products. MK4 and MK7 are the two most significant forms of K2, and act very differently in your body:

•MK4 is a synthetic product, very similar to vitamin K1, and your body is capable of converting K1 into MK4. However, MK4 has a very short half-life of about one hour, making it a poor candidate as a dietary supplement. After reaching your intestines, it remains mostly in your liver, where it is useful in synthesizing blood-clotting factors.
•MK7 is a newer agent with more practical applications because it stays in your body longer; its half-life is three days, meaning you have a much better chance of building up a consistent blood level, compared to MK4 or K1. MK7 is extracted from the Japanese fermented soy product called natto. You could actually get loads of MK7 from consuming natto as it is relatively inexpensive, and is available in most Asian food markets. Few people, however, tolerate it’s smell and slimy texture.
Let’s take a look at what scientific studies are showing us about vitamin K2.

Vitamin K Research has Come a Long Way
In 2008, a German research group discovered that vitamin K2 provides substantial protection from prostate cancer[1], which is one of the leading causes of cancer among men in the United States. According to Dr. Vermeer, men taking the highest amounts of K2 have about 50 percent less prostate cancer.

Research results are similarly encouraging for the benefits of vitamin K to your cardiac health:

•In 2004, the Rotterdam Study, which was the first study demonstrating the beneficial effect of vitamin K2, showed that people who consume 45 mcg of K2 daily live seven years longer than people getting 12 mcg per day[2].
•In a subsequent study called the Prospect Study[3], 16,000 people were followed for 10 years. Researchers found that each additional 10 mcg of K2 in the diet results in 9 percent fewer cardiac events.
Preliminary findings also suggest that vitamin K can help protect you from brain disease. However, it is too early to say exactly what types of damage it prevents—and how—but it is an area of intense interest to vitamin K scientists right now.

Vitamin K2 is CRUCIAL in Preventing Osteoporosis
The evidence suggests that vitamin K2 is essential for your bone health, but it is a nutrient the vast majority of you do not get in adequate amounts from your diet.

How does vitamin K lead to bone health?

Osteocalcin is a protein produced by your osteoblasts (cells responsible for bone formation), and is utilized within the bone as an integral part of the bone-forming process. However, osteocalcin must be “carboxylated” before it can be effective. Vitamin K functions as a cofactor for the enzyme that catalyzes the carboxylation of osteocalcin.

Vitamin K2 has been found to be a far more effective “activator” of osteocalcin than K1.

There has been some remarkable research about the protective effects of vitamin K2 against osteoporosis:

•A number of Japanese trials have shown that vitamin K2 completely reverses bone loss and in some cases even increases bone mass in people with osteoporosis[4].
•The pooled evidence of seven Japanese trials show that vitamin K2 supplementation produces a 60 percent reduction in vertebral fractures and an 80 percent reduction in hip and other non-vertebral fractures[5].
•Researchers in the Netherlands showed that vitamin K2 is three times more effective than vitamin K1 in raising osteocalcin, which controls the building of bone[6].
Although your body can convert K1 into K2, studies show that the amount of K2 produced by this process alone is insufficient. Even if you are consuming enough K1, your body uses most of it to make clotting factors, leaving little remaining for your bones.

In other words, your liver preferentially uses vitamin K1 to activate clotting factors, while most of your other tissues preferentially use K2.

Vitamin K2 has also been found to offer you other benefits—besides your bones!

Vitamin K2 Lowers Your Cancer Risk
As mentioned earlier, we are also learning that vitamin K2 has a major role in preventing cancer.

The recent European Prospective Investigation into Cancer and Nutrition (EPIC) study[7], published in the March 2010 issue of the American Journal of Clinical Nutrition, found high intake of vitamin K2—not K1—leads to reduced cancer risk, as well as a thirty percent lower risk of dying from cancer[8].

A study funded by the National Cancer Institute found that vitamin K2 might help reduce the risk for non-Hodgkin lymphoma. Mayo Clinic researchers discovered that people with the highest intake of vitamin K2 had a 45 percent lower risk for this type of cancer, compared to those with the lowest vitamin K2 intake[9].

Scientists attribute this to the important role that vitamin K2 plays in inhibiting inflammatory cytokines, which are related to this type of lymphoma, and vitamin K’s role the lifecycle of your cells.

Are You Getting Enough Vitamin K from Your Diet?
Eating lots of green vegetables will increase your vitamin K1 levels naturally, especially:

•Kale
•Spinach
•Collard greens
•Broccoli
•Brussels sprouts
You can obtain all the K2 you’ll need (about 200 micrograms) by eating 15 grams of natto daily, which is half an ounce. However, natto is generally not pleasing to the Westerner’s palate, so the next best thing is a vitamin K2 supplement.

But remember, you must always take your vitamin K supplement with fat since it is fat-soluble and won’t be absorbed without it.

Although the exact dosing is yet to be determined, Dr. Vermeer recommends between 45 mcg and 185 mcg daily for adults. You must use caution on the higher doses if you take anticoagulants, but if you are generally healthy and not on these types of medications, I suggest 150 mcg daily.

Fortunately, you don’t need to worry about overdosing on K2—people have been given a thousand-fold “overdose” over the course of three years, showing no adverse reactions (i.e., no increased clotting tendencies).

The Synergistic Effects Between Vitamin K and Vitamin D
It’s important to realize that vitamin K does not work alone. It needs collaborators—and vitamin D is an important one.

These two agents work together to increase MGP, or Matrix GLA Protein, which is the protein that is responsible for protecting your blood vessels from calcification. In fact, MGP is so important that it can be used as a laboratory measure of your vascular and cardiac status.

The results of human clinical studies suggest that concurrent use of vitamin K2 and vitamin D may substantially reduce bone loss.

If you are concerned about your bones, you must balance this nutritional triad:

1.Vitamin D
2.Vitamin K
3.Calcium
Increasing calcium is good for your bones but not so beneficial for your arteries, which can become calcified, but vitamin K protects your blood vessels from calcifying when in the presence of high calcium levels.

So you really must pay attention to the synergism of all three of these nutrients if you want to optimize your benefits.

I am convinced we are seeing just the tip of the iceberg when it comes to vitamin K and its many valuable functions in your health. It’s truly an exciting area in nutritional science today.

In the meantime it is my STRONG encouragement to make sure you find some regular source of vitamin K2. This will mean eating about four ounces of fermented cheese a day (preferably raw) or taking a high quality vitamin K2 supplement.

It is my strong belief that in ten years time there will be as much passion and appreciation for this stealth vitamin as we have for vitamin D today.

References

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[1] Nimptsch K, Rohrmann S and Linseisen J. “Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)” Am J Clinical Nutrition April 2008;87(4):985-992
[2] Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MHJ, van der Meer IM, Hofman A and Witteman JCM. “Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study” November 2004; J Nutr 134:3100-3105
[3] Daniels, S. “Vitamin K2, but not K1, effective for heart health benefits: Study” NutraIngredients.com February 12, 2009
[4] Vermeer C, Shearer M J, Zitterman A, Bolton-Smith C, Szulc P, Hodges S, Walter P, Rambeck W, Stocklin E, Weber P. “Beyond deficiency: Potential benefits of increased intakes of vitamin K for bone and vascular health” Eur J Nutr. December 2004;43(6):325-335
[5] Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ. “Vitamin K and the prevention of fractures: Systematic review and meta-analysis of randomized controlled trials” Arch Intern Med. 2006; 166: 1256-1261
[6] Schurgers LJ, Teunissen KJF, Hamulyak K, Knapen MHJ, Hogne V, Vermeer C. “Vitamin K-containing dietary supplements: Comparison of synthetic vitamin K1 and natto-derived menaquinone-7” Blood. 2006
[7] Nimptsch K, Rohrmann S, Kaaks R, and Linseisen J. “Dietary vitamin K intake in relation to cancer incidence and mortality: Results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)” Am J Clin Nutr (March 24, 2010)
[8] Daniells S (March 30, 2010) “Vitamin D may reduce cancer risk: EPIC study” Nutraingredients.com
[9] “Vitamin K may protect against developing non-Hodgkin lymphoma” (April 20, 2010)